MyOme tau nthuav tawm cov ntaub ntawv los ntawm daim ntawv tshaj tawm ntawm American Society of Human Genetics (ASHG) lub rooj sib tham uas tau tsom mus rau kev sib koom ua ke polygenic txaus ntshai qhab nia (caIRS), uas sib txuas cov noob caj noob ces nrog cov tshuaj kho mob ib txwm muaj los txhim kho kev txheeb xyuas cov neeg muaj kev pheej hmoo siab rau kab mob plawv. (CAD) thoob plaws ntau haiv neeg.
Cov txiaj ntsig tau pom tias caIRS tau txheeb xyuas tau tseeb dua cov tib neeg uas muaj kev pheej hmoo siab rau kev tsim kab mob plawv, tshwj xeeb tshaj yog nyob rau hauv ciam teb lossis cov chaw kho mob nruab nrab thiab rau cov neeg Esxias sab qab teb.
Raws li kev lig kev cai, feem ntau CAD cov cuab yeej ntsuas kev pheej hmoo thiab kev ntsuas tau raug lees paub ntawm cov pej xeem nqaim, raws li Akash Kumar, MD, PhD, tus kws kho mob thiab kws tshawb fawb ntawm MyOme.Cov cuab yeej siv feem ntau, Atherosclerotic Cardiovascular Disease (ASCVD) Pooled Cohort Equation (PCE), tso siab rau cov qauv ntsuas xws li qib roj cholesterol thiab ntshav qab zib kom kwv yees 10-xyoo CAD kev pheej hmoo thiab qhia kev txiav txim siab txog kev pib kho statin, sau tseg Kumar .
Integates tsheej lab ntawm cov noob caj noob ces
Cov qhab nia Polygenic txaus ntshai (PRS), uas suav nrog ntau lab tus kab mob sib txawv ntawm cov txiaj ntsig me me rau hauv ib qho qhab nia, muab lub peev xwm los txhim kho qhov tseeb ntawm cov cuab yeej soj ntsuam kev pheej hmoo, "Kumar txuas ntxiv.MyOme tau tsim thiab ua pov thawj qhov kev pheej hmoo sib xyaw ua ke uas sib xyaw ua ke PRS hla kev nrog caIRS.
Cov kev tshawb pom tseem ceeb los ntawm qhov kev nthuav qhia tau pom tias caIRS tau txhim kho kev ntxub ntxaug ntau dua piv rau PCE hauv txhua pawg pab pawg thiab cov poj koob yawm txwv tau sim.Lub caIRS kuj tau txheeb xyuas txog li 27 tus neeg mob CAD ntxiv rau 1,000 tus neeg hauv pawg ciam teb / nruab nrab PCE.Tsis tas li ntawd, cov neeg Esxias Qab Teb tau nthuav tawm qhov kev ntxub ntxaug ntau ntxiv.
"MyOme cov qhab nia muaj kev pheej hmoo tuaj yeem txhim kho kev tiv thaiv kab mob thiab kev tswj hwm hauv kev saib xyuas thawj zaug los ntawm kev txheeb xyuas cov tib neeg uas muaj kev pheej hmoo siab ntawm kev txhim kho CAD, leej twg yuav tsis tau txais lwm yam," Kumar hais."Qhov tseem ceeb, caIRS tau txais txiaj ntsig zoo hauv kev txheeb xyuas cov neeg Esxias sab qab teb muaj kev pheej hmoo rau CAD, uas yog qhov tseem ceeb vim lawv yuav luag ob npaug ntawm CAD cov neeg tuag piv rau cov neeg European."
Daim ntawv tshaj tawm ntawm Myome tau muaj npe "Kev koom ua ke ntawm Polygenic Risk Scores nrog Clinical Factors Txhim Kho 10-xyoo Risk Prediction of Coronary Artery Disease."
Post lub sij hawm: Nov-10-2023